When Tottenham and Arsenal meet, there's guaranteed to be plenty riding on the outcome regardless of their respective positions in the league table.
But Saturday lunchtime's clash at Wembley will genuinely have a major impact on the race to finish in the top four.
If Arsenal complete the double over their North rivals, they will move within a point of Spurs in third place, a scenario that seemed unthinkable just a few weeks ago.
We take a look at some of the key questions ahead of what will doubtless be a tasty encounter.
Can Tottenham's title aspirations be resurrected?
Back-to-back losses to Burnley and Chelsea this week have made it incredibly difficult for Mauricio Pochettino's side to claim the title from here.
With 10 matches remaining, they trail leaders Liverpool by nine points and second-placed Manchester City by eight. While Liverpool have lost once in the league this season and City four times, Spurs have now lost eight times.
The one small glimmer of hope for Spurs is that they still have to travel to Liverpool on March 31 and City on April 20.
Can Arsenal finish above their rivals?
Of course, it used to so commonplace that Arsenal would finish ahead of their north London rivals in the table their fans invented the movable feast of St Totteringham's Day to celebrate their supremacy.
But the last few years have seen the tables turned and it looked highly likely a month ago that Spurs would finish ahead of Arsenal by a double-digit points margin.
Indeed, 10 points split Spurs in third from Arsenal in fifth on February 10. But Tottenham's collapse in form has coincided with a run of five wins in six league games for the Gunners to close that gap to four points.
Will Harry Kane return to form?
It's curious to think that Spurs fans were so desperate to get their top scorer Kane back fit and firing following his ankle ligament injury but his comeback has coincided with two defeats.
During his absence, Spurs won four consecutive league matches against Fulham, Watford, Newcastle United and Leicester City. They also beat Borussia Dortmund 3-0 in the Champions League.
Can Mesut Ozil get back to his best?
Mesut Ozil's travails have been well-documented this season. The German has been in and out of the Arsenal side, never entirely trusted by Emery and absent through a variety of injuries and illnesses.
The manager appeared to signal that he was approaching the end of his tether with Ozil last week when he demanded he stop making excuses and find some consistency in form and fitness.
The message seems to be getting through - Ozil was influential in Arsenal's 5-1 rout of Bournemouth on Wednesday night, scoring with his trademark chop finish and creating another goal.
Can Pochettino keep up his excellent record against Arsenal?
Tottenham used to have a real inferiority complex in north London derbies - they'd won just four of 36 encounters with Arsenal prior to Pochettino's arrival in the summer of 2014.
Since the Argentine arrived, they have gone five Premier League home matches against their main rivals without suffering a defeat, winning three of them.
Pochettino spoke of his team having to overcome a psychological problem when they faced the Gunners and they seem to have managed that.
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