Marcus Rashford was on target twice with Jesse Lingard and Antony Martial adding the other two goals. Elsewhere Michy Bashtuayi grabbed a hat-trick as Chelsea thrashed Nottingham Forest 5-1, Arsenal beat Doncaster one nil while Manchester City were 2-1 winners against West Brom.
Tottenham will host West Ham in an-all London derby in the fourth round of the Carabao Cup.
The tie between Mauricio Pochettino and Slaven Bilic's bitter rivals is the pick of the ties for the last 16, which sees Chelsea face Everton at Stamford Bridge.
They are two of just three all-Premier League ties, completed by Manchester United's trip to Swansea.
Elsewhere Arsenal host Championship outfit Norwich and Wolves will take on Manchester City at the Etihad Stadium.
Roy Hodgson's Crystal Palace go away to Bristol City while Championship-toppers Leeds face Leicester at the King Power Stadium.
The final clash picked out of the pot sees Bournemouth host Middlesbrough.
Dates and times of the fixtures are to be finalised at a later date but will take place on October 23/24.
-Dailymail